Systemic sclerosis is an autoimmune disease that is caused by the immune system reacting with skin and other organs. This causes fibroblast activity to rise and therefore an abnormal growth of connective tissue.
Stem cells are produced in the bone marrow. They are immature cells that have the potential to self-generate themselves into many different cell types in the body. Stem cell therapy is an opportunity to alter the progression of systemic sclerosis.
Firstly, the stem cells are collected from the patient’s bone marrow and stored. The patient will then receive extremely high doses of chemotherapy, this virtually destroys the immune system so that the body can re-learn how to defend itself. The stem cells are then implanted back into the body with the aim to regenerate the immune system and therefore produce blood cells free of the autoimmune antibodies that cause the disease.